Abstract : For motor-disabled patients with Stroke or brain tumor, one of the most effective treatments is to induce reorganization of the motor cortex and related areas damaged by neurological disorders to restore its own function. However, this potentially requires a computational model of its network based on an understanding of the movement-related cerebral cortex and subcortical regions from the cellular to the systems level. In this talk, we introduce the major findings of brain-machine interface approach to stroke patients that we obtained so far. In addiiton, we demonstrate an attempt to apply this approach to stroke patients through both exoskeleton and brain-machine interface for their physical and occupational therapies. Based on these preliminary studies, we suggest a plan of computer modeling approach to efficient rehabilitation for Stroke patients and other neurological disorder patients to recover their motor function.